Human Sera
Cayman Chemical MosaprIdecItrate 100mg
A Nur77 receptor agonist selectively activates Nur77 over PPARY in reporter assays at 20 M inhibits growth of and induces apoptosis in L3 6pL pancreatic cancer cells at 10 15 and 20 M stabilizes nuclear localization of Nur77 and Nurr1 and reduces secretion of pro-inflammatory cytokines in primary mouse astrocytes oral administration prevents loss of dopaminergic neurons in the substantia nigra pars compacta and striatal dopamine terminals in a mouse model of MPTP-induced Parkinsons disease at 50 mg/kg
Cayman Chemical Fenvalerate 50mg
A triacylglycerol has been found in ostrich and emu oils as well as cow milk fat
Cayman Chemical Pulsatla korna Ajmaln 50mg
A synthetic polypeptide and CCK2 receptor agonist binds selectively to CCK2 in guinea pig brain over CCK1 receptors in rat pancreas (IC50s 11 and 1100 nM respectively) increases calcium influx and polyphosphoinositide turnover in rat GH3 pituitary cells (EC50s 23 and 3 9 nM respectively) increases histidine decarboxylase activity in mucous and endocrine cell-enriched isolated rabbit fundic mucosal cells (EC50 2 9 nM) induces contraction of isolated pig ileum smooth muscle cells in vitro (EC50 30 pM) increases gastric acid and pepsin secretion in conscious cats in vivo (ED50s 1 29 and 57 3 nmol/kg2 per hour respectively)
Cayman Chemical ClothInIdIn 50mg
The fluorescent form of lysoFP-NO2 formed when lysoFP-NO2 reacts with CO ex/em 440/528 nm respectively
Cayman Chemical 6Chloro3IndolylDGlucur 100mg
An inhibitor of Plk1 (IC50 2 nM) selective for Plk1 over Plk2 and Plk3 (IC50s 10000 nM for both) inhibits proliferation of A2780 cells (IC50 42 nM) halts the cell cycle at the G2/M phase in A2780 cells at 20-200 nmol/L and induces apoptosis reduces tumor growth in an HCT116 mouse xenograft model at 60 mg/kg once per day induces tumor regression in an HT-29 mouse xenograft model at 45 mg/kg in combination with CPT11
Cayman Chemical Frtlara thunberg Pemn 50mg
A triterpenoid saponin inhibits NMDA-evoked currents in hippocampal neurons (IC50s 18 48 and 20 19 M at -50 and 50 mV respectively) and inhibits NMDA-induced neuronal cell death at 30 M increases the levels of 5-HT 5-HIAA and norepinephrine in the hippocampus and 5-HIAA and norepinephrine in the prefrontal cortex in mice at 30 and 100 mg/kg reduces the time spent immobile in the forced swim test in mice at 30 and 100 mg/kg increases the time spent in the target quadrant of the Morris water maze in mice at 100 mg/kg reduces infarct volume in an MCAO rat model of ischemia at 12 6 and 25 2 mg/kg induces relaxation of precontracted isolated rat thoracic aorta and renal mesenteric and left coronary arteries in a concentration-dependent manner
Cayman Chemical 5-DeoxyadenosIn 50mg
A fungal metabolite with diverse biological activities inhibits production of TBARS in vitro (IC50 0 55 g/ml) inhibits AAPH-induced hemolysis in rat erythrocytes (IC50 1 95 g/ml) is active against C albicans (MIC 1 64 g/ml) cytotoxic in a panel of 21 cancer cell lines (EC50s 0 10-7 04 g/ml) inhibits gelatinase A (IC50 15 2 M)
Cayman Chemical ZINC00881524 100mg
A pentapeptide decreases IL-8 secretion in human keratinocytes when used in combination with acetyl hexapeptide-36 and acetyl hexapeptide-38
Cayman Chemical CLOrcyclIzInhydroCLOrID 100mg
A cationic porphyrin that intercalates into and stabilizes G-quadruplexes inhibits telomerase activity (IC50 50 UM) blocking the clonogenic growth and migration of cancer cells in culture and in vivo
Cayman Chemical D-Mnose-6-PhosphatesodIum 50mg
A selective inhibitor of EZH2 that prevents the methyltransferase activity of wild-type and mutant EZH2 with similar potency (apparent Ki 3-27 nM) effective in vivo in mouse models of cancer
Cayman Chemical RhodamIn B IsothIocynATm 100mg
A naturally-occurring tropane alkaloid that serves as an intermediate in the synthesis of a variety of bioactive alkaloids many of which have potent neurological actions
Cayman Chemical SKF 38393hydrobromIde 50mg
A cephalosporin antibiotic that is effective against E coli (MIC values range from 0 25-2 mg/L depending on strain) as well as H influenza and S aureus
Cayman Chemical NaftIfInhydrochlorIde 50mg
A specific adenosine A2 receptor agonist with antipyretic and anticonvulsant activity stimulates the production of cyclic AMP in CHO-K1 cells with an EC50 value of 5 3 UM