Human Sera
Cayman Chemical ApomorphInhydrochlorId 100mg
A non-selective dopamine receptor agonist (pKis = 6.43, 7.08, 7.59, 8.36, and 7.83 for human recombinant D1, D2L, D3, D4, and D5 receptors, respectively); produces biphasic effects on locomotor activity and displays anti-Parkinsonian and neuroprotective actions
Cayman Chemical AlarelInacetate 100mg
A peptide agonist of GnRH; binds to GnRHR (Kd = 0.2 nM); decreases GnRH and GnRHR expression in the preoptic area and pMBH, respectively, of ovariectomized estradiol-treated rats at 6 ng, i.c.v., indicating an ultrashort negative feedback loop; induces desensitization in the pituitary and decreases serum estradiol levels and ovarian and uterine weight in neonatal and adult female rats; reduces tumor growth in an HEC-1-B mouse xenograft model at 20, 40, and 80 UG/mg
Cayman Chemical namInhydrochlorIde 100mg
A natural degradation product of neomycin; a common core molecule used in the synthesis of aminoglycoside antibiotics
Cayman Chemical Apararenon 50mg
A non-steroidal mineralocorticoid receptor antagonist (Ki = 0.104 µM for the human receptor); selective for mineralocorticoid receptors over ERα and ERβ and glucocorticoid, progesterone, and androgen receptors (IC50s = >100 µM for all); increases the urinary ratio of sodium to potassium in adrenalectomized rats; inhibits aldosterone- and nephrectomy-induced increases in systolic blood pressure and urinary albumin levels, as well as myocardial necrosis and fibrosis, cardiac arterial degeneration, and renal tubule damage, in a rat model of renal hypertension at 3 or 10 mg/kg per day
Cayman Chemical PIcrocrocIn 50mg
A monoterpene glycoside with anticancer activity; a biosynthetic precursor of safranal; inhibits the growth of HeLa cells (IC50 = 3 mM)
Cayman Chemical nagrelIdehydrochlorIde 50mg
A PDE3 inhibitor (IC50 = 36 nM for the human platelet enzyme); inhibits thrombopoietin-induced megakaryocytopoiesis of isolated human CD34+ progenitor cells (IC50 = 26 nM); reduces ADP-, collagen-, thrombin-, or arachidonic acid-induced platelet aggregation in isolated rabbit platelet rich-plasma (EC50s = 0.31, 0.08, 0.18, and 0.1 UG/ml, respectively); inhibits platelet thrombus formation in a dog model of electrically induced carotid artery thrombosis when administered at 0.5-5 mg/kg
Cayman Chemical 6 9DICLOro1 2 3 4tetrahyd 50mg
A synthetic intermediate in the synthesis of AChE inhibitors
Cayman Chemical fluoro-DapaglIflozIn 50mg
An analog of dapagliflozin that displays similar selectivity for inhibiting SGLT2 over SGLT1 (Kis = 5.3 and 330 nM, respectively); significantly reduces phlorizin-sensitive sugar transport in COS-1 cells expressing human SGLT2
Cayman Chemical ClemastInfumarate 100mg
A histamine H1 receptor antagonist (Ki = 0.26 nM); selective for the histamine H1 receptor over mAChRs (Ki = 16 nM), as well as over σ1 and σ2 and α2A-, α2B-, and α2C-adrenergic receptors (Kis = 67, 15, 1,365, 691, and 545 nM, respectively); reduces ovalbumin-induced bronchial obstruction in ovalbumin-sensitized guinea pigs alone or in combination with cimetidine at 0.12 mg/kg; decreases SARS-CoV-2 replication in SARS-CoV-2-infected Vero E6 cells (EC50 = 0.95 µM)
Cayman Chemical C4 CeramIded18 14 0 250mg
A bioactive sphingolipid; inhibits IL-4 production by 16% in PMA-stimulated EL4 T cells at 10 μM; cytotoxic to SK-BR-3 and MCF-7/Adr breast cancer cells (IC50s = 15.9 and 19.9 μM, respectively); increases maturation and stability of F508del-CFTR proteins, enhances cAMP-activated chloride secretion, and suppresses secretion of IL-8 in primary epithelial cells isolated from patients with cystic fibrosis
Cayman Chemical ClIndamycIn 100mg
A lincosamide antibiotic; active against Gram-positive bacteria, including various strains of S. pneumoniae, S. viridans, S. aureus, and S. epidermidis (MICs = 0.002-0.1, 0.005-0.2, 0.04-1.6, and 0.1-0.2 UG/ml, respectively); active against chloroquine-resistant and -sensitive strains of P. falciparum (IC50s = 3.12 and 8.81 nM, respectively); inhibits bacterial protein synthesis by interacting with the 50S ribosome; increases survival in a mouse model of a secondary S. pneumoniae infection at 15 mg/kg twice daily for seven days
Abcam SATA (N-Succinimidyl-S-acetylthioacetate), Protein modification thiolating reagent, 100MG
MW 231.23 Da, Purity >94%. Primary amine-reactive protein modification thiolating reagent. Adds protected sulfhydryls to targeted proteins. Induces stable recombinant TNF-α trimer formation by formation of disulfide bridges between reactive thiol groups on adjacent TNF-α molecules, which show increased therapeutic efficacy in vivo. .
The product is subject to the following: Abcam Restricted Use Statement
Cayman Chemical HydrocortIson Aceponate 50mg
A corticosteroid; reduces lesion size and pruritis in cats with allergic dermatitis when applied topically at 0.0584%; induces remission and increases time to relapse in dogs with spontaneous atopic dermatitis
